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Another factor responsible for reduced healing is reduced fibroblast, PMN, and epithelial cell function as well as reduced host defense response

"Our analyses show that there is significant toxicity in harm reduction products, and reduction of carcinogens in harm reduction mainstream smoke does not necessarily reduce the toxicity of unfiltered sidestream smoke." Researchers developed tests with human embryonic stem cells, which are similar to young embryos, to compare the toxicity of mainstream (inhaled) smoke and sidestream smoke from both conventional and harm reduction cigarette brands

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Formaldehyde is found in many things certain building materials, disinfectants and embalming fluid